剧集讲述暖海镇刑警胡文静与市禁毒警金龙正联手，在小镇复杂的熟人关系网中，追查伪装成日常用品的新型毒品案件，胡文静突破情感与现实的多重纠葛，最终捣毁贩毒链条、守护小镇安宁的缉毒故事。
剧根据英国同名剧集改编。 本剧主演 William H. Macy 曾获得艾美奖。 拥有有六个孩子的单身父亲 Frank（威廉姆·H·梅西 William H. Macy 饰）和孩子们生活在周围到处是酒鬼、乞丐和罪犯的最底层社区。他收入不高，整天酗酒，根本不管儿女们的死活，不到20岁的大女儿 Fiona（埃米·罗森 Emmy Rossum 饰）不得不承担起照顾五个弟妹以及养家糊口的责任。跨过宿醉的父亲的身体争抢着偷来的早餐；凌晨4点大开着摇滚乐狂欢；纵容邻居在他们的楼梯上做爱；这个热闹非凡的家庭忙碌、自由、无法无天、充满冒险。他们拥有的不多，但他们懂得生活中最重要的是什么……
新興毒品「粉精靈」流竄市面，臥底潘奕風（馬貫東 飾）潛伏多年，終令真正製毒師一權世豪（杜燕歌 飾）被拘捕。但世豪金蟬脫殼獲得輕判！奕風為提防世豪出獄後會讓「粉精靈」再度肆虐，請求上司批准他組織臥底小組，調查向世豪提供原材料的上線，圖能將整條黑暗製毒鍊連根拔起。 奕風找來三名各擅勝場的臥底嬌娃一「女版福爾摩斯」沈佳琪（張曦雯 飾）、「細心敏銳武術通」江妙姿（陳瀅 飾）、「百孌行走數據庫」童小茹（羅毓儀飾），以美貌設陷阱、以感性作利刃、以智慧當盔甲，接近目標人物一表面上是慈善商家劉彪（關禮傑 飾）和卡邦妮（邵美琪 飾）夫婦，及其背後的四聯商會。四聯商會勢力龐大，滴水不漏，唯一突破點便是劉氏夫婦的女兒劉寶儀（鍾柔美 飾）。 奕風此次任務雖然獲得直屬上司禤步青（黃子雄 飾）鼎力支持，卻被鄰組警司郭宗南（黃子恆 飾）懷疑他在任臥底期間，早已變節。奕風挺著腹背受敵的壓力，卻諱莫如深的推動著三名女臥底進行各種危機重重的行動，原來奕風懷著一個自私的目的，想借這次任務，想為受涉而喪命的女友討回公道。
As Murder, She Wrote saunters through its sixth (of an eventual 12) season, star Angela Lansbury maintains her eternally buoyant and inquisitive air as Jessica Fletcher, professional writer and amateur sleuth. Though Jessica continued to investigate murders in her home town of Cabot Cove and elsewhere (in the worlds of high finance, opera, and voodoo, among other settings), this season began the practice of guest detective episodes, introduced by Jessica as either a story she wrote or a tale told by a friend, but starring a variety of quirky investigators: An ex-football player (Ken Howard, The White Shadow) paired with a clever poodle; a television crime-show producer who solved crime in real life (Diana Canova, Soap); a stout Irish detective (longtime character actor Pat Hingle); an abrasive homicide cop (Barry Newman, Vanishing Point); as well as recurring Murder, She Wrote characters like former jewel thief Dennis Stanton (Keith Michell) and British secret agent Michael Haggerty (Len Cariou). The producers were obviously hoping to use Murder, She Wrote's popularity to spin-off new series, but nothing from this season took off and viewer resistance soon brought the practice to an end. Executives must have been surprised to discover that, though murder mysteries are plot-driven, this show's success depends heavily on the undeniable charm of star Lansbury. Still, these one-off episodes are of a consistent quality with Lansbury's, and viewers open to variety will enjoy them just as much. The rest of the season features the usual astonishing array of guests, including movie stars old (Donald O'Connor, Singin' in the Rain) and recent (Elliott Gould, The Long Goodbye), television stalwarts (Shirley Jones, The Partridge Family; Jerry Stiller, The King of Queens; Doris Roberts, Everyone Loves Raymond; Kevin Tighe, Battlestar Galactica; and Gavin McLeod, The Love Boat), and D-list celebrities to die for (Dack Rambo, Morgan Brittany, Susan Anton, and more).
