本剧聚焦赖斯“吸血鬼编年史”等作品中涉及的神秘组织Talamasca，“保护世界免受女巫、吸血鬼、狼人和别的怪物和超自然世界的危害”。而Guy Anatole的角色描述为：“外表聪明、英俊、时髦，但他一直知道自己的头脑运作跟别人不太一样。在从法学院毕业前夕，他被秘密机构Talamasca的人找上了，并发现自己从幼年时期起就在被该机构追踪。因此，Guy进入了一个秘密特工和不死生物的世界。如今，这些永生者与人类世界维持着一种脆弱的平衡，但要保持这种平衡，并且保住Guy的性命，他必须要学会接受黑暗、狡诈、奇特的真正自我。”
浩瀚的太空，飞行员约翰突遇意外事件，被宇航船抛出，陷入一个奇异的星际轨道。他穿梭1000个星系到达了一个神秘的星球，那里漂浮着地球传说中遥远的“摩亚方舟”飞船，飞船里有来自不同星球的成员，他们都是无家可归的人。约翰决定加入他们，并带领大家寻找地球道路但他们不曾料到，众多 的外星人和外星生物早已对地球航线虎视耽耽。在飞行过程中，“摩亚”遇到了“和平卫士”的追击，双方数次激战，在一次混战中，“和平卫士”首脑克瑞斯痛失弟弟，发誓要用尽一切手段将“摩亚”摧毁变成一屡轻烟与此同时，“摩亚”水晶能量器忽然失踪，约翰断定是内奸所为，决定展开锄奸行动......经过多次交锋，“摩亚”粉碎了克瑞斯阴谋，逃出生天。因核反应堆动力装置破裂。“摩亚”降落在西卡行星上进行紧急维修。无意中，约翰发现了飞船上隐匿已久的危机和一个重大的阴谋......约翰经过一次次战斗的洗礼，逐渐成为一个真正的领袖，而“摩亚”也慢慢聚集了巨大的能量，击退了外星战舰的数次围攻，“摩亚”战士们一步步向地球前进......约翰终于找到了回地球的航线，并成功降落到地球，然而，此时的地球已不再是他们心目中理想的家园......
九一八事变之后,抗日呼声日益高涨，苏海龙和黄显声打响了沈阳城抗击日寇的第一枪。在养父和亲人的相继离去后，苏海龙走出悲情，积极组建抗日队伍，与邓铁梅一道加入东北抗日革命军。在张婉婷的影响帮助下，苏海龙光荣地加入了中国共产党，带领部队给予日本关东军以沉痛的打击。日本关东军对苏海龙所在的部队进行了多次围剿。随着抗日斗争的形势逐渐严峻，东北抗联奉命相继进入苏联远东地区进行休整。苏海龙奉命前往延安抗大学习，学习结束后，苏海龙被派往苏联远东第88步兵旅。苏海龙多次率领小分队进入东北，对日本关东军进行渗透和侦查，成功炸毁虎头要塞号称“亚洲第一炮”的巨型榴弹炮，为日后的总攻扫清了障碍。
At the beginning of 2259, Captain John Sheridan replaces Sinclair as the military governor of the station. He and the command staff learn that the death of President Santiago was actually an assassination masterminded by Vice President Clark (who assumed the Presidency upon Santiago's death). A conflict develops between the Babylon 5 command staff and the Psi Corps, an increasingly autocratic organization which oversees and controls the lives of human telepaths. Commander Ivanova, the second-in-command of the station, is secretly a latent telepath who has illicitly avoided registering with the Psi Corps. The Shadows, an ancient and extremely powerful race who have recently emerged from hibernation, are revealed to be the cause of a variety of mysterious and disturbing events, including the attack on the Narn outpost at the end of 2258. Centauri Ambassador Londo Mollari unknowingly enlists their aid through his association with the mysterious Mr. Morden in the ongoing conflict with the Narn. The elderly and ailing Centauri emperor, long an advocate of reconciliation with the Narn, dies suddenly while visiting Babylon 5. A number of conspirators, including Londo Mollari and Refa, take control of the Centauri government by assassinating their opponents and placing the late emperor's unstable nephew on the throne. Their first act is to start open aggression against the Narn. After a full-scale war breaks out, the Centauri eventually conquer Narn in a brutal attack involving mass drivers, outlawed weapons of mass destruction. Towards the end of the year, the Clark administration begins to show increasingly totalitarian characteristics, clamping down on dissent and restricting freedom of speech. The Vorlons are revealed to be the basis of legends about angels on various worlds, including Earth, and are the ancient enemies of the Shadows. They enlist the aid of Sheridan and the Babylon 5 command staff in the struggle against the Shadows.
