骊城公安局最年轻的法医齐思哲（罗云熙饰），因一场车祸失去了女友俞菲，但他发觉意外的背后似乎隐藏着神秘的幕后推手。为了调查真相，齐思哲入职成为河城市公安局的刑侦法医，却被迫卷入一桩桩令人细思极恐的奇诡悬案之中，身亡许久的被害者被重重蛛丝包裹，失踪的尸体出现在标本室的福尔马林中……在侦破过程中，他与祝青越（刘雅瑟饰），韩烽（江奇霖饰）强强联合，抽丝剥茧屡破奇案，而牵涉当年俞菲之死的“原钻”毒品案，也逐渐展露冰山一角……
阿泽（范少勋 饰）为了筹措妹妹欣爱的换心手术费，决心卖掉自住二十年的凶宅，却意外加入专门买卖凶宅的“义胜房屋”。办公室寒酸，头顶日光灯闪个不停，同事也各有怪癖：抽烟抖脚又沉迷手游的勇仁、消息灵通的殡葬业者馒头、神算毕婆婆，以及拥有灵异体质的孙女小墨。某晚，阿泽独自在凶宅整理时，听见小孩笑声，一把刀突从空中飞来，所幸小墨及时现身拯救。之后，这群风格迥异的房仲杂牌军，又迎来新加入的美女业务员李静，众人携手踏上凶宅买卖之路。每次进入凶宅，除了安抚亡灵，也不得不面对内心的创伤，每一场灵异事件背后，藏着难以言说的情绪与遗憾。
剧根据英国同名剧集改编。 本剧主演 William H. Macy 曾获得艾美奖。 拥有有六个孩子的单身父亲 Frank（威廉姆·H·梅西 William H. Macy 饰）和孩子们生活在周围到处是酒鬼、乞丐和罪犯的最底层社区。他收入不高，整天酗酒，根本不管儿女们的死活，不到20岁的大女儿 Fiona（埃米·罗森 Emmy Rossum 饰）不得不承担起照顾五个弟妹以及养家糊口的责任。跨过宿醉的父亲的身体争抢着偷来的早餐；凌晨4点大开着摇滚乐狂欢；纵容邻居在他们的楼梯上做爱；这个热闹非凡的家庭忙碌、自由、无法无天、充满冒险。他们拥有的不多，但他们懂得生活中最重要的是什么……
As Murder, She Wrote saunters through its sixth (of an eventual 12) season, star Angela Lansbury maintains her eternally buoyant and inquisitive air as Jessica Fletcher, professional writer and amateur sleuth. Though Jessica continued to investigate murders in her home town of Cabot Cove and elsewhere (in the worlds of high finance, opera, and voodoo, among other settings), this season began the practice of guest detective episodes, introduced by Jessica as either a story she wrote or a tale told by a friend, but starring a variety of quirky investigators: An ex-football player (Ken Howard, The White Shadow) paired with a clever poodle; a television crime-show producer who solved crime in real life (Diana Canova, Soap); a stout Irish detective (longtime character actor Pat Hingle); an abrasive homicide cop (Barry Newman, Vanishing Point); as well as recurring Murder, She Wrote characters like former jewel thief Dennis Stanton (Keith Michell) and British secret agent Michael Haggerty (Len Cariou). The producers were obviously hoping to use Murder, She Wrote's popularity to spin-off new series, but nothing from this season took off and viewer resistance soon brought the practice to an end. Executives must have been surprised to discover that, though murder mysteries are plot-driven, this show's success depends heavily on the undeniable charm of star Lansbury. Still, these one-off episodes are of a consistent quality with Lansbury's, and viewers open to variety will enjoy them just as much. The rest of the season features the usual astonishing array of guests, including movie stars old (Donald O'Connor, Singin' in the Rain) and recent (Elliott Gould, The Long Goodbye), television stalwarts (Shirley Jones, The Partridge Family; Jerry Stiller, The King of Queens; Doris Roberts, Everyone Loves Raymond; Kevin Tighe, Battlestar Galactica; and Gavin McLeod, The Love Boat), and D-list celebrities to die for (Dack Rambo, Morgan Brittany, Susan Anton, and more).
